AKOS B018304
Product Specifications
CAS Number
6308-22-1
Synonyms
C6; NSC 43396
Target
Others
Applications
Others
Smiles
C1=CC=C (C (=C1) C=C2C (=O) NC (=S) S2) [N+] (=O) [O-]
Molecular Formula
C10H6N2O3S2
Additionnal Information
AKOS B018304 (C6; NSC 43396) is an arylalkylidene derivative with a polar substitution at the para-position. It functions as an inhibitor of ΔFosB by allosterically inhibiting its binding to DNA. It disrupts ΔFosB binding to TMR-cdk5 with an IC50 value of 10.1 μM and also induces a structural change in ΔFosB that prevents the protein from binding to DNA.
Storage Conditions
3 years -20°C powder
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