MAC-545496
Product Specifications
CAS Number
838810-96-1
Target
Anti-infection
Applications
Microbiology
Smiles
C1CCN (CC1) C2=C (C=C (C=C2) C (=O) NC (=S) NC3=NC=C (C=C3) Cl) [N+] (=O) [O-]
Molecular Formula
C18H18ClN5O3S
Additionnal Information
MAC-545496 is a nanomolar glycopeptide-resistance-associated protein R (GraR) inhibitor with strong binding affinity to the full-length GraR protein (Kd ≤ 0.1 nM) . MAC-545496 can reverse β-lactam resistance in methicillin-resistant strains and synergize with CAMPs. MAC-545496 shows remarkable activity in macrophages and attenuates S. aureus virulence in a G. mellonella larvae infection model.
Storage Conditions
3 years -20°C powder
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