TOFA
Product Specifications
CAS Number
54857-86-2
Synonyms
5- (Tetradecyloxy) -2-furoic acid, RMI14514; MDL14514
Target
Acetyl-CoA carboxylase
Applications
Metabolism
Smiles
CCCCCCCCCCCCCCOC1=CC=C (O1) C (=O) O
Molecular Formula
C19H32O4
Additionnal Information
TOFA is an allosteric inhibitor of acetyl-CoA carboxylase-α (ACCA) . Inside the cell, TOFA is converted to TOFyl-CoA (5-tetradecyloxy-2-furoyl-CoA), exerting an allosteric inhibition on ACCA. TOFA blocks fatty acid synthesis and induces cell death in a dose-dependent manner.
Storage Conditions
3 years -20°C powder
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