MRT67307
Product Specifications
CAS Number
1190378-57-4
Synonyms
IKKε/TBK1 Inhibitor II
Target
TBK1
Applications
Immunology & Inflammation
Smiles
O=C (NCCCNC1=NC (=NC=C1C2CC2) NC3=CC=CC (=C3) CN4CCOCC4) C5CCC5
Molecular Formula
C26H36N6O2
Additionnal Information
MRT67307 (IKKε/TBK1 Inhibitor II) inhibits IKKε and TBK1 with IC50 values of 160 nM and 19 nM at 0.1 mM ATP in vitro, but does not inhibit IKKα or IKKβ even at 10 μM. MRT67307 also is a highly potent ULK1 and ULK2 inhibitor with IC50s of 45 and 38 nM, respectively. MRT67307 can blocks autophagy in cells.
Storage Conditions
3 years -20°C powder
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