5'-N-Ethylcarboxamidoadenosine (NECA)

Product Specifications

CAS Number

35920-39-9

Synonyms

5'- (N-Ethylcarboxamido) adenosine, Adenosine-5'N-ethylcarboxamide, 5'-Ethylcarboxamidoadenosine

Target

Adenosine Receptor

Applications

GPCR & G Protein

Smiles

CCNC (=O) C1OC (C (O) C1O) [N]2C=NC3=C (N) N=CN=C23

Molecular Formula

C12H16N6O4

Additionnal Information

5'-N-Ethylcarboxamidoadenosine (NECA, 5'- (N-Ethylcarboxamido) adenosine, Adenosine-5'N-ethylcarboxamide, 5'-Ethylcarboxamidoadenosine) is a stable, nonselective adenosine receptor agonist. 5'-N-Ethylcarboxamidoadenosine acts via multiple mechanisms including: reducing diabetes-induced oxidative stress, inhibiting gene expression of IL-18, TNF-α and ICAM-1 (intercellular adhesion molecule 1 (CD54) ), and blocking activation of the JNK-MAPK pathway.