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PMX-53

Product Specifications

CAS Number

219639-75-5

Target

Immunology & Inflammation related

Applications

Immunology & Inflammation

Smiles

CC (=O) NC (CC1=CC=CC=C1) C (=O) NC2CCCNC (=O) C (CCCN=C (N) N) NC (=O) C (CC3=C[NH]C4=CC=CC=C34) NC (=O) C (CC5CCCCC5) NC (=O) C6CCCN6C2=O

Molecular Formula

C47H65N11O7

Additionnal Information

PMX-53 is a potent CD88 (C5aR) antagonist and inhibits C5a-induced neutrophil myeloperoxidase release and chemotaxis with IC50 values of 22 nM and 75 nM, respectively. PMX-53 is also an agonist of Mas-related gene 2 (MrgX2) .

Storage Conditions

3 years -20°C powder

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