YUM70
Product Specifications
CAS Number
423145-35-1
Target
HSP (HSP90)
Applications
Cytoskeletal Signaling
Smiles
CCCC (=O) NC (C1=CC2=C (OCO2) C=C1) C3=CC (=C4C=CC=NC4=C3O) Cl
Molecular Formula
C21H19ClN2O4
Additionnal Information
YUM70 is a potent inhibitor of glucose-regulated protein 78 (GRP78) inhibitor with an IC50 of 1.5 μM. YUM70 induces endoplasmic reticulum (ER) stress-mediated apoptosis in pancreatic cancer.Although YUM70 inhibits GRP78 enzymatic activity, it increases the expression of GRP78 by increasing the chaperone translation mechanism.
Storage Conditions
3 years -20°C powder
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