Berberine chloride hydrate
Product Specifications
CAS Number
68030-18-2
Synonyms
Natural Yellow 18 chloride hydrate
Target
Anti-infection
Applications
Microbiology
Smiles
O.[Cl-].COC1=C (OC) C2=C[N+]3=C (C=C2C=C1) C4=CC5=C (OCO5) C=C4CC3
Molecular Formula
C20H20ClNO5
Additionnal Information
Berberine (Natural Yellow 18) chloride hydrate is a quaternary ammonium salt from the group of isoquinoline alkaloids. Berberine activates caspase 3 and caspase 8, cleavage of poly ADP-ribose polymerase (PARP) and the release of cytochrome c. Berberine chloride decreases the expression of c-IAP1, Bcl-2 and Bcl-XL. Berberine chloride induces apoptosis with sustained phosphorylation of JNK and p38 MAPK, as well as generation of the ROS. Berberine chloride is a dual topoisomerase I and II inhibitor. Berberine chloride is also a potential autophagy modulator.
Storage Conditions
3 years -20°C powder
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