Tacrolimus monohydrate
Product Specifications
CAS Number
109581-93-3
Synonyms
Tacrolimus, FK506
Target
Phosphatase
Applications
Metabolism
Molecular Formula
C44H69NO12.H2O
Additionnal Information
Tacrolimus monohydrate (Tacrolimus, FK506) is a macrolide antibiotic that primarily acts as an inhibitor of calcineurin phosphatase by binding to FK506 binding protein (FKBP) . This inhibition blocks calcium-dependent processes, including interleukin-2 gene transcription, nitric oxide synthase activation, cell degranulation, and apoptosis, and also has immunosuppressive, neuroregenerative and neuroprotective properties.
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