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Tacrolimus monohydrate

Product Specifications

CAS Number

109581-93-3

Synonyms

Tacrolimus, FK506

Target

Phosphatase

Applications

Metabolism

Molecular Formula

C44H69NO12.H2O

Additionnal Information

Tacrolimus monohydrate (Tacrolimus, FK506) is a macrolide antibiotic that primarily acts as an inhibitor of calcineurin phosphatase by binding to FK506 binding protein (FKBP) . This inhibition blocks calcium-dependent processes, including interleukin-2 gene transcription, nitric oxide synthase activation, cell degranulation, and apoptosis, and also has immunosuppressive, neuroregenerative and neuroprotective properties.

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