CYP51-IN-17

CYP51-IN-17 (compound 7a) is a potent CYP51 inhibitor with an IC50 of 0.377 μg/mL. CYP51-IN-17 shows significant fungicidal activity against B. cinerea with an EC50 of 0.326 μg/mL[1].

Product Specifications

UNSPSC

12352005

Target

Bacterial; Cytochrome P450; Fungal

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/cyp51-in-17.html

Smiles

O=C(C(C1C2=CC=CO2)=C(N)OC3=C1CN(C(C4=CC=CO4)=O)C/C3=C\C5=CC=CO5)OC

Molecular Formula

C24H20N2O7

Molecular Weight

448.42

References & Citations

[1]Bao A, et al. Design, Synthesis, Bioactive Evaluation, and Molecular Dynamics Simulation of Novel 4 H-Pyrano [3, 2-c] pyridine Analogues as Potential Sterol 14α-Demethylase (CYP51) Inhibitors[J]. Journal of Medicinal Chemistry, 202