Rolapitant

Product Specifications

CAS Number

552292-08-7

Synonyms

SCH-619734

Target

Neurokinin Receptor

Applications

Neuronal Signaling

Smiles

CC (C1=CC (=CC (=C1) C (F) (F) F) C (F) (F) F) OCC2 (CCC3 (CCC (=O) N3) CN2) C4=CC=CC=C4

Molecular Formula

C25H26F6N2O2

Additionnal Information

Rolapitant (SCH-619734) is a selective and competitive antagonist of human substance P/NK1 receptors with antiemetic activity. It has a high affinity for the human NK1 receptor of 0.66 nM and high selectivity over the human NK2 and NK3 subtypes of >1000-fold, as well as preferential affinity for human, guinea pig, gerbil and monkey NK1 receptors over rat, mouse and rabbit.