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Methotrexate disodium

Product Specifications

CAS Number

7413-34-5

Synonyms

Amethopterin disodium; CL14377 disodium; WR19039 disodium

Target

DHFR

Applications

Cell Cycle

Smiles

CN (CC1=CN=C2C (=N1) C (=NC (=N2) N) N) C3=CC=C (C=C3) C (=O) NC (CCC (=O) [O-]) C (=O) [O-].[Na+].[Na+]

Molecular Formula

C20H20N8O5.2Na

Additionnal Information

Methotrexate sodium, an analog of folic acid, is a nonspecific inhibitor of the dihydrofolate reductase (DHFR) of bacteria and cancerous cells as well as normal cells. It forms an inactive ternary complex with DHFR and NADPH. Methotrexate (MTX) induces apoptosis.

Storage Conditions

2 years -80 in solvent

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