Methotrexate disodium
Product Specifications
CAS Number
7413-34-5
Synonyms
Amethopterin disodium; CL14377 disodium; WR19039 disodium
Target
DHFR
Applications
Cell Cycle
Smiles
CN (CC1=CN=C2C (=N1) C (=NC (=N2) N) N) C3=CC=C (C=C3) C (=O) NC (CCC (=O) [O-]) C (=O) [O-].[Na+].[Na+]
Molecular Formula
C20H20N8O5.2Na
Additionnal Information
Methotrexate sodium, an analog of folic acid, is a nonspecific inhibitor of the dihydrofolate reductase (DHFR) of bacteria and cancerous cells as well as normal cells. It forms an inactive ternary complex with DHFR and NADPH. Methotrexate (MTX) induces apoptosis.
Storage Conditions
2 years -80 in solvent
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