Simeprevir
Product Specifications
CAS Number
923604-59-5
Synonyms
TMC435, TMC-435350
Target
HCV Protease
Applications
Proteases
Smiles
CC1=C (C=CC2=C1N=C (C=C2OC3CC4C (C3) C (=O) N (CCCCC=CC5CC5 (NC4=O) C (=O) NS (=O) (=O) C6CC6) C) C7=NC (=CS7) C (C) C) OC
Molecular Formula
C38H47N5O7S2
Additionnal Information
Simeprevir is a competitive, reversible, macrocyclic, noncovalent hepatitis C virus (HCV) NS3/4A protease inhibitor that acts directly against the hepatitis C virus. It has a medium inhibitory concentration (IC50) <13 nM for all HCV NS3/4A enzymes (genotypes 1a, 1b, 2, 4, 5, and 6), but has an IC50 value of 37 nM for genotype 3.
Storage Conditions
2 years -80 in solvent
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