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Tacrolimus (FK506)

Product Specifications

CAS Number

104987-11-3

Synonyms

FR900506, Fujimycin

Target

Phosphatase

Applications

Metabolism

Smiles

CC1CC (C2C (CC (C (O2) (C (=O) C (=O) N3CCCCC3C (=O) OC (C (C (CC (=O) C (C=C (C1) C) CC=C) O) C) C (=CC4CCC (C (C4) OC) O) C) O) C) OC) OC

Molecular Formula

C44H69NO12

Additionnal Information

Tacrolimus (FK506) is a 23-membered macrolide lactone, it reduces peptidyl-prolyl isomerase activity in T cells by binding to the immunophilin FKBP12 (FK506 binding protein) creating a new complex. Tacrolimus also inhibits the phosphatase activity of calcineurin. Tacrolimus induces vascular endothelial autophagy.

Storage Conditions

2 years -80 in solvent

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