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JNK-IN-8

Product Specifications

CAS Number

1410880-22-6

Synonyms

JNK Inhibitor XVI

Target

JNK

Applications

MAPK

Smiles

CC1=C (C=CC (=C1) NC (=O) C2=CC (=CC=C2) NC (=O) C=CCN (C) C) NC3=NC=CC (=N3) C4=CN=CC=C4

Molecular Formula

C29H29N7O2

Additionnal Information

JNK-IN-8 (JNK Inhibitor XVI) is the first irreversible JNK inhibitor for JNK1, JNK2 and JNK3 with IC50 of 4.7 nM, 18.7 nM and 1 nM, >10-fold selectivity against MNK2, Fms and no inhibition to c-Kit, Met, PDGFRβin A375 cell line.

Storage Conditions

2 years -80 in solvent

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