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Nilotinib hydrochloride monohydrate

Product Specifications

CAS Number

923288-90-8

Synonyms

Tasigna, AMN-107 hydrochloride monohydrate

Target

Bcr-Abl

Applications

Protein Tyrosine Kinase

Smiles

O.Cl.CC1=C[N] (C=N1) C2=CC (=CC (=C2) NC (=O) C3=CC (=C (C) C=C3) NC4=NC=CC (=N4) C5=CN=CC=C5) C (F) (F) F

Molecular Formula

C28H25ClF3N7O2

Additionnal Information

Nilotinib (AMN-107, Tasigna) hydrochloride monohydrate is a selective and orally bioavailable inhibitor of Bcr-Abl with IC50 < 30 nM in Murine myeloid progenitor cells. Nilotinib induces autophagy through AMPK activition.

Storage Conditions

3 years -20°C powder

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