Thymectacin
Thymectacin (NB1011) is an agent selectively targeting tumor cells that have a high expression of thymidylate synthase (TS) . Thymectacin is an aryloxy phosphoramidate derivative of BVdU (brivudin) [1][2].
Product Specifications
CAS Number
232925-18-7
Product Name Alternative
NB1011
UNSPSC
12352005
Target
Thymidylate Synthase
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/thymectacin.html
Purity
98.21
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O[C@H]1C[C@H](N2C=C(/C=C/Br)C(NC2=O)=O)O[C@@H]1COP(N[C@@H](C)C(OC)=O)(OC3=CC=CC=C3)=O
Molecular Formula
C21H25BrN3O9P
Molecular Weight
574.32
References & Citations
[1]Wilson RH. Novel therapeutic developments other than EGFR and VEGF inhibition in colorectal cancer. Oncologist. 2006;11 (9) :1018-1024.|[2] Congiatu C, et al. Novel potential anticancer naphthyl phosphoramidates of BVdU: separation of diastereoisomers and assignment of the absolute configuration of the phosphorus center. J Med Chem. 2006;49 (2) :452-455.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
Frequently Asked Questions
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