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Trametinib DMSO solvate

Product Specifications

CAS Number

1187431-43-1

Synonyms

GSK1120212, JTP-74057

Target

MEK

Applications

Protein Tyrosine Kinase

Smiles

CN1C (=O) C (=C2N (C (=O) N (C3CC3) C (=O) C2=C1NC4=C (F) C=C (I) C=C4) C5=CC=CC (=C5) NC (C) =O) C.C[S] (C) =O

Molecular Formula

C28H29FIN5O5S

Additionnal Information

Trametinib DMSO solvate is a highly specific and potent MEK1/2 inhibitor with IC50 of 0.92 nM/1.8 nM in cell-free assay. Trametinib activates autophagy and induces apoptosis.

Storage Conditions

3 years -20°C powder

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