PCNA-I1
Product Specifications
CAS Number
444930-42-1
Target
DNA/RNA Synthesis
Applications
Cell Cycle
Smiles
CC1=C (SC=C1) C (=O) N\N=C\C2=C (O) C3=CC=CC=C3C=C2
Molecular Formula
C17H14N2O2S
Additionnal Information
PCNA-I1 is a selective inhibitor of proliferating cell nuclear antigen (PCNA, a potential anticancer target) . PCNA-I1 selectively binds to PCNA trimers with Kd of ~0.2 to 0.4 μM. PCNA-I1 inhibits the growth of tumor cells of various tissue types with IC50 of ~0.2 μM. PCNA-I1 induces DNA damage and apoptosis in both LNCaP and PC-3 cells. PCNA-I1 also induces autophagy in PC-3 cells.
Storage Conditions
3 years -20°C powder
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