Terfenadine

Product Specifications

CAS Number

50679-08-8

Target

Potassium Channel

Applications

Transmembrane Transporters

Smiles

CC (C) (C) C1=CC=C (C=C1) C (CCCN2CCC (CC2) C (C3=CC=CC=C3) (C4=CC=CC=C4) O) O

Molecular Formula

C32H41NO2

Additionnal Information

Terfenadine is an antihistamine, generally completely metabolizes to the active form fexofenadine in the liver by the enzyme cytochrome P450 CYP3A4 isoform. Terfenadine ((±) -Terfenadine) is a potent open-channel blocker of hERG with an IC50 of 204 nM. Terfenadine, an H1 histamine receptor antagonist, acts as a potent apoptosis inducer in melanoma cells through modulation of Ca2+ homeostasis. Terfenadine induces ROS-dependent apoptosis, simultaneously activates Caspase-4, -2, -9.