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Pimethixene maleate

Product Specifications

CAS Number

13187-06-9

Synonyms

Pimetixene maleate

Target

5-HT Receptor

Applications

Neuronal Signaling

Smiles

CN1CCC (CC1) =C2C3=CC=CC=C3SC4=CC=CC=C24.OC (=O) \C=C/C (O) =O

Molecular Formula

C23H23NO4S

Additionnal Information

Pimethixene (Pimetixene) maleate, an antihistamine, anntimigraine agent and antiserotonergic compound, is a highly potent antagonist of a broad range of monoamine receptors, including a variety of serotonin receptors. Pimethixene maleate inhibits 5-HT2A, 5-HT2B, 5-HT2C, 5-HT1A, 5-HT1B, 5-HT6, 5-HT7, Adrenergic α-1A, Dopamine D1 Receptor, Dopamine D2 Receptor, Dopamine D4.4 Receptor, Histamine H1 Receptor, Muscarinic M1 and Muscarinic M2 with pKi of 10.22, 10.44, 8.42, 7.63, < 5, 7.30, 7.28, 7.61, 6.37, 8.19, 7.54, 10.14, 8.61 and 9.38, respectively.

Storage Conditions

3 years -20°C powder

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