Triptolide
Product Specifications
CAS Number
38748-32-2
Synonyms
PG490, NSC 163062
Target
NF-κB
Applications
NF-κB
Molecular Formula
C20H24O6
Additionnal Information
Triptolide is a diterpene triepoxide, immunosuppresive agent extracted from the Chinese herb Tripterygium wilfordii. It functions as a NF-κB inhibitor with dual actions by disruption of p65/CBP interaction and by reduction of p65 protein. Triptolide (PG490) abrogates the transactivation function of heat shock transcription factor 1 (HSF1) . Triptolide inhibits MDM2 and induces apoptosis through a p53-independent pathway.
Storage Conditions
2 years -80 in solvent
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