What is the catalog number for SIS3?

The catalog number for SIS3 is S3552-1g.

What sizes are available for SIS3?

SIS3 is available in the following size(s): 1 g.

SIS3 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures SIS3?

SIS3 is manufactured by Bimake.

What is the estimated delivery time for SIS3?

Estimated delivery time for SIS3 is approximately 15 business day(s), depending on your location.

SIS3

Product Specifications

CAS Number

1009104-85-1

Target

TGF-beta/Smad

Applications

TGF-beta/Smad

Smiles

COC1=CC2=C (CN (CC2) C (=O) \C=C\C3=C ([N] (C) C4=NC=CC=C34) C5=CC=CC=C5) C=C1OC

Molecular Formula

C28H27N3O3

Additionnal Information

SIS3 is a cell-permeable inhibitor of Smad3 that selectively inhibits TGF-β1-dependent Smad3 phosphorylation and Smad3-mediated cellular signaling. SIS3 reduces TGF-β1-induced type 1 procollagen expression and myofibroblast differentiation in normal dermal fibroblasts as well as scleroderma fibroblasts.