Caulophylline (N-Methylcytisine)
Product Specifications
CAS Number
486-86-2
Synonyms
Caulophyllin, NMC
Target
AChR
Applications
Neuronal Signaling
Smiles
CN1CC2CC (C1) C3=CC=CC (=O) N3C2
Molecular Formula
C12H16N2O
Additionnal Information
Caulophylline (N-Methylcytisine, Caulophyllin, NMC) is a tricyclic quinolizidine alkaloid with anti-inflammatory activities. Caulophylline binds to nicotinic acetylcholine receptors (nAChR) from squid optical ganglia with Kd of 50 nM. Caulophylline significantly reduces myeloperoxidase (MPO) activity, blocks the activation of NF-κB by inhibiting IκB and IKK phosphorylation.
Storage Conditions
3 years -20°C powder
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