Senkyunolide I

Product Specifications

CAS Number

94596-28-8

Synonyms

SEI, SENI

Target

ERK

Applications

MAPK

Smiles

CCC\C=C1/OC (=O) C2=C1CCC (O) C2O

Molecular Formula

C12H16O4

Additionnal Information

Senkyunolide I (SEI, SENI) is an orally active compound isolated from Ligusticum chuanxiong with analgesic, anti-migraine, neuroprotective, anti-oxidation and anti-apoptosis activities. Senkyunolide I (SEI, SENI) up-regulates the phosphorylation of Erk1/2 and induces Nrf2 nuclear translocation with enhanced HO-1 and NQO1 expressions. Senkyunolide I (SEI, SENI) promotes the ratio of Bcl-2/Bax and inhibits the expressions of cleaved caspase 3 and caspase 9.