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Loureirin B

Product Specifications

CAS Number

119425-90-0

Synonyms

LB, LrB

Target

PAI-1

Applications

Metabolism

Smiles

COC1=CC (=C (CCC (=O) C2=CC=C (O) C=C2) C (=C1) OC) OC

Molecular Formula

C18H20O5

Additionnal Information

Loureirin B (LB, LrB), a flavonoid extracted from Dracaena cochinchinensis, is an inhibitor of PAI-1 with IC50 of 26.10 μM. Loureirin B downregulates p-ERK and p-JNK in TGF-β1-stimulated fibroblasts. Loureirin B promotes insulin secretion mainly through increasing Pdx-1, MafA, intracellular ATP level, inhibiting the KATP current, influx of Ca2+ to the intracellular.

Storage Conditions

3 years -20°C powder

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