Loureirin B
Product Specifications
CAS Number
119425-90-0
Synonyms
LB, LrB
Target
PAI-1
Applications
Metabolism
Smiles
COC1=CC (=C (CCC (=O) C2=CC=C (O) C=C2) C (=C1) OC) OC
Molecular Formula
C18H20O5
Additionnal Information
Loureirin B (LB, LrB), a flavonoid extracted from Dracaena cochinchinensis, is an inhibitor of PAI-1 with IC50 of 26.10 μM. Loureirin B downregulates p-ERK and p-JNK in TGF-β1-stimulated fibroblasts. Loureirin B promotes insulin secretion mainly through increasing Pdx-1, MafA, intracellular ATP level, inhibiting the KATP current, influx of Ca2+ to the intracellular.
Storage Conditions
3 years -20°C powder
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