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UCB-9260

Product Specifications

CAS Number

1515888-53-5

Target

TNF-alpha

Applications

Apoptosis

Smiles

C[N]1C=C (C=N1) C2=CC3=C (C=C2) N=C (C (O) C4=CC=NC=C4) [N]3CC5=C (C) C=CC (=C5) C

Molecular Formula

C26H25N5O

Additionnal Information

UCB-9260 is an orally active inhibitor that inhibits TNF signalling by stabilising an asymmetric form of the trimer. UCB-9260 binds TNF with Kd of 13 nM. UCB-9260 also inhibits NF-κB with IC50 of 202 nM after TNF stimulation.

Storage Conditions

3 years -20°C powder

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