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Pazopanib

Product Specifications

CAS Number

444731-52-6

Synonyms

GW786034

Target

C-Kit

Applications

Protein Tyrosine Kinase

Smiles

CC1=C (C=C (C=C1) NC2=NC=CC (=N2) N (C) C3=CC4=NN (C (=C4C=C3) C) C) S (=O) (=O) N

Molecular Formula

C21H23N7O2S

Additionnal Information

Pazopanib (GW786034) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms/CSF1R with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM in cell-free assays, respectively. Pazopanib induces cathepsin B activation and autophagy.

Storage Conditions

2 years -80 in solvent

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