Pazopanib
Product Specifications
CAS Number
444731-52-6
Synonyms
GW786034
Target
C-Kit
Applications
Protein Tyrosine Kinase
Smiles
CC1=C (C=C (C=C1) NC2=NC=CC (=N2) N (C) C3=CC4=NN (C (=C4C=C3) C) C) S (=O) (=O) N
Molecular Formula
C21H23N7O2S
Additionnal Information
Pazopanib (GW786034) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms/CSF1R with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM in cell-free assays, respectively. Pazopanib induces cathepsin B activation and autophagy.
Storage Conditions
2 years -80 in solvent
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