SEC inhibitor KL-1
Product Specifications
CAS Number
900308-84-1
Synonyms
KL-1
Target
Others
Applications
Others
Smiles
COC1=CC=CC (=C1) C (=O) CC (=O) C (=O) NC2=C (C) C=CC (=C2) Cl
Molecular Formula
C18H16ClNO4
Additionnal Information
SEC inhibitor KL-1 (KL-1) is a potent and selective inhibitor of super elongation complex (SEC) that disrupts the interaction between the SEC scaffolding protein AFF4 and P-TEFb, resulting in impaired release of Pol II from promoter-proximal pause sites and a reduced average rate of processive transcription elongation. KL-1 exhibits an dose-dependent inhibitory effect on AFF4-CCNT1 interaction with Ki of 3.48 μM.
Storage Conditions
3 years -20°C powder
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