Dooku1

Product Specifications

CAS Number

2253744-54-4

Target

Mechanosensitive Channel

Applications

Transmembrane Transporters

Smiles

ClC1=C (CSC2=NN=C (O2) C3=CC=C[NH]3) C (=CC=C1) Cl

Molecular Formula

C13H9Cl2N3OS

Additionnal Information

Dooku1 is an analog of Yoda1 with antagonist activity against mechanosensitive Piezo1 channel. Dooku1 inhibits 2 μM Yoda1-induced Ca2+-entry with IC50 of 1.3 μM in HEK 293 cells and 1.5 μM in HUVECs, respectively.

Storage Conditions

3 years -20°C powder

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