IOX2

Product Specifications

CAS Number

931398-72-0

Synonyms

JICL38

Target

HIF

Applications

Angiogenesis

Smiles

C1=CC=C (C=C1) CN2C3=CC=CC=C3C (=C (C2=O) C (=O) NCC (=O) O) O

Molecular Formula

C19H16N2O5

Additionnal Information

IOX2 (JICL38) is a potent inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2) with IC50 of 21 nM in a cell-free assay, >100-fold selectivity over JMJD2A, JMJD2C, JMJD2E, JMJD3, or the 2OG oxygenase FIH.

Storage Conditions

2 years -80 in solvent

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