IKK-16
Product Specifications
CAS Number
873225-46-8
Synonyms
IKK Inhibitor VII
Target
IκB/IKK
Applications
NF-κB
Smiles
C1CCN (C1) C2CCN (CC2) C (=O) C3=CC=C (C=C3) NC4=NC=CC (=N4) C5=CC6=CC=CC=C6S5
Molecular Formula
C28H29N5OS
Additionnal Information
IKK-16 is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM in cell-free assays, respectively. IKK-16 also inhibits LRRK2 Ser935 phosphorylation in cells and LRRK2 kinase activity in vitro with IC50 of 50 nM.
Storage Conditions
2 years -80 in solvent
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