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Baricitinib

Product Specifications

CAS Number

1187594-09-7

Synonyms

INCB028050, LY3009104

Target

JAK

Applications

Angiogenesis

Smiles

CCS (=O) (=O) N1CC (C1) (CC#N) N2C=C (C=N2) C3=C4C=CNC4=NC=N3

Molecular Formula

C16H17N7O2S

Additionnal Information

Baricitinib is a selective JAK1 and JAK2 inhibitor with IC50 of 5.9 nM and 5.7 nM in cell-free assays, ~70 and ~10-fold selective versus JAK3 and Tyk2, no inhibition to c-Met and Chk2. Baricitinib is found to reduce or interrupt the passage of the virus into target cells and is used in the treatment research for COVID-19. Phase 3.

Storage Conditions

2 years -80 in solvent

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