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SAR131675

Product Specifications

CAS Number

1433953-83-3

Target

VEGFR

Applications

Protein Tyrosine Kinase

Smiles

CCN1C (=C (C (=O) C2=C1N=C (C=C2) C#CC (C) (COC) O) C (=O) NC) N

Molecular Formula

C18H22N4O4

Additionnal Information

SAR131675 is a VEGFR3 inhibitor with IC50/Ki of 23 nM/12 nM in cell-free assays, about 50- and 10-fold more selective for VEGFR3 than VEGFR1/2, little activity against Akt1, CDKs, PLK1, EGFR, IGF-1R, c-Met, Flt2 etc.

Storage Conditions

2 years -80 in solvent

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