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TPCA-1

Product Specifications

CAS Number

507475-17-4

Synonyms

GW683965

Target

IκB/IKK

Applications

NF-κB

Smiles

C1=CC (=CC=C1C2=CC (=C (S2) NC (=O) N) C (=O) N) F

Molecular Formula

C12H10FN3O2S

Additionnal Information

TPCA-1 (GW683965) is an inhibitor of IKK-2 with IC50 of 17.9 nM in a cell-free assay, inhibits NF-κB pathway, exhibits 22-fold selectivity over IKK-1. TPCA-1 is also an inhibitor of STAT3 and enhances apoptosis.

Storage Conditions

2 years -80 in solvent

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