Sapanisertib (MLN0128)
Product Specifications
CAS Number
1224844-38-5
Synonyms
INK 128, TAK-228
Target
MTOR
Applications
PI3K/Akt/mTOR
Smiles
CC (C) N1C2=NC=NC (=C2C (=N1) C3=CC4=C (C=C3) OC (=N4) N) N
Molecular Formula
C15H15N7O
Additionnal Information
Sapanisertib (MLN0128, INK 128, TAK-228) is a potent and selective mTOR inhibitor with IC50 of 1 nM in cell-free assays; >200-fold less potent to class I PI3K isoforms, superior in blocking mTORC1/2 and sensitive to pro-invasion genes (vs Rapamycin) . Phase 1.
Storage Conditions
2 years -80 in solvent
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