Fexagratinib (AZD4547)
Product Specifications
CAS Number
1035270-39-3
Synonyms
ABSK 091
Target
FGFR
Applications
Protein Tyrosine Kinase
Smiles
CC1CN (CC (N1) C) C2=CC=C (C=C2) C (=O) NC3=NNC (=C3) CCC4=CC (=CC (=C4) OC) OC
Molecular Formula
C26H33N5O3
Additionnal Information
Fexagratinib (AZD4547, ABSK 091) is a novel selective FGFR inhibitor targeting FGFR1/2/3 with IC50 of 0.2 nM/2.5 nM/1.8 nM in cell-free assays, weaker activity against FGFR4, VEGFR2 (KDR), and little activity observed against IGFR, CDK2, and p38. Phase 2/3.
Storage Conditions
2 years -80 in solvent
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