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Tofacitinib

Product Specifications

CAS Number

477600-75-2

Synonyms

CP-690550, Tasocitinib

Target

JAK

Applications

Angiogenesis

Smiles

CC1CCN (CC1N (C) C2=NC=NC3=C2C=CN3) C (=O) CC#N

Molecular Formula

C16H20N6O

Additionnal Information

Tofacitinib is a novel inhibitor of JAK3 with IC50 of 1 nM in cell-free assays, 20- to 100-fold less potent against JAK2 and JAK1. Tofacitinib inhibits the expression of antiapoptotic BCL-A1 and BCL-XL in human plasmacytoid dendritic cells (PDC) and induced PDC apoptosis.

Storage Conditions

2 years -80 in solvent

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