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Vistusertib (AZD2014)

Product Specifications

CAS Number

1009298-59-2

Target

MTOR

Applications

PI3K/Akt/mTOR

Smiles

CC1COCCN1C2=NC (=NC3=C2C=CC (=N3) C4=CC (=CC=C4) C (=O) NC) N5CCOCC5C

Molecular Formula

C25H30N6O3

Additionnal Information

Vistusertib (AZD2014) is a novel mTOR inhibitor with IC50 of 2.8 nM in a cell-free assay; highly selective against multiple PI3K isoforms (α/β/γ/δ) . AZD2014 showed no or weak binding to the majority of kinases when tested at 1 μM. AZD2014 induces proliferation suppression, apoptosis, cell cycle arrest, and autophagy in HCC cells with antitumor activity.

Storage Conditions

2 years -80 in solvent

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