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PF-5274857

Product Specifications

CAS Number

1373615-35-0

Target

Hedgehog/Smoothened

Applications

Stem Cells & Wnt

Smiles

CC1=CC (=C (N=C1) C2=CC (=NC=C2Cl) N3CCN (CC3) C (=O) CCS (=O) (=O) C) C

Molecular Formula

C20H25ClN4O3S

Additionnal Information

PF-5274857 is a potent and selective Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 and Ki of 5.8 nM and 4.6 nM, respectively, and can penetrate the blood–brain barrier.

Storage Conditions

2 years -80 in solvent

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