Tivantinib
Product Specifications
CAS Number
905854-02-6
Synonyms
ARQ 197
Target
C-Met
Applications
Protein Tyrosine Kinase
Smiles
C1CC2=C3C (=CC=C2) C (=CN3C1) C4C (C (=O) NC4=O) C5=CNC6=CC=CC=C65
Molecular Formula
C23H19N3O2
Additionnal Information
Tivantinib is the first non-ATP-competitive c-Met inhibitor with Ki of 0.355 μM in a cell-free assay, little activity to Ron, and no inhibition to EGFR, InsR, PDGFRα or FGFR1/4. Tivantinib (ARQ 197) induces a G2/M arrest and apoptosis.
Storage Conditions
2 years -80 in solvent
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