Fedratinib (TG101348)
Product Specifications
CAS Number
936091-26-8
Synonyms
SAR302503
Target
JAK
Applications
Angiogenesis
Smiles
CC1=CN=C (N=C1NC2=CC (=CC=C2) S (=O) (=O) NC (C) (C) C) NC3=CC=C (C=C3) OCCN4CCCC4
Molecular Formula
C27H36N6O3S
Additionnal Information
Fedratinib (SAR302503, TG101348) is a selective inhibitor of JAK2 with IC50 of 3 nM in cell-free assays, 35- and 334-fold more selective for JAK2 versus JAK1 and JAK3. Fedratinib also inhibits FMS-like tyrosine kinase 3 (FLT3) and RET (c-RET) with IC50 of 15 nM and 48 nM, respectively. Fedratinib has potential antineoplastic activity. Fedratinib inhibits proliferation and induces apoptosis. Phase 2.
Storage Conditions
2 years -80 in solvent
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