Ibrutinib
Product Specifications
CAS Number
936563-96-1
Synonyms
PCI-32765
Target
BTK
Applications
Protein Tyrosine Kinase
Smiles
C=CC (=O) N1CCCC (C1) N2C3=NC=NC (=C3C (=N2) C4=CC=C (C=C4) OC5=CC=CC=C5) N
Molecular Formula
C25H24N6O2
Additionnal Information
Ibrutinib is a potent and highly selective Brutons tyrosine kinase (Btk) inhibitor with IC50 of 0.5 nM in cell-free assays, modestly potent to Bmx, CSK, FGR, BRK, HCK, less potent to EGFR, Yes, ErbB2, JAK3, etc. Ibrutinib is applicable as a Btk ligand in the synthesis of a series of PROTACs including P13I.
Storage Conditions
2 years -80 in solvent
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