Flavopiridol (Alvocidib) HCl
Product Specifications
CAS Number
131740-09-5
Synonyms
NSC 649890, L86-8275, HMR-1275, DSP-2033
Target
CDK
Applications
Cell Cycle
Smiles
CN1CCC (C (C1) O) C2=C (C=C (C3=C2OC (=CC3=O) C4=CC=CC=C4Cl) O) O.Cl
Molecular Formula
C21H20ClNO5.HCl
Additionnal Information
Flavopiridol (Alvocidib) HCl competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM in cell-free assays. It is 7.5-fold more selective for CDK1/2/4/6 than CDK7. Flavopiridol is initially found to inhibit EGFR and PKA. Flavopiridol HCl induces autophagy and ER stress. Flavopiridol HCl blocks HIV-1 replication. Phase 1/2.
Storage Conditions
2 years -80 in solvent
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC742216-500 1x 500 µL
CD50 / ICAM3 (CG106), CF740 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC700391-100 1x 100 µL
CD81 / TAPA-1 (1.3.3.22), CF770 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC681922-100 1x 100 µL
TPO (Thyroid Peroxidase) (Thyroid Marker) (TPO/1922), CF568 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC881825-100 1x 100 µL
Gp100 / Melanosome / PMEL17 / SILV (Melanoma Marker) (PMEL/1825R), CF488A conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC042747-500 1x 500 µL
TCL1 (T-Cell Marker) (TCL1/2747R), CF405S conjugate, 0.1mg/mL
Sign In for Pricing
View Details