NU7441 (KU-57788)
Product Specifications
CAS Number
503468-95-9
Target
DNA-PK
Applications
PI3K/Akt/mTOR
Smiles
C1COCCN1C2=CC (=O) C3=C (O2) C (=CC=C3) C4=CC=CC5=C4SC6=CC=CC=C56
Molecular Formula
C25H19NO3S
Additionnal Information
NU7441 (KU-57788) is a highly potent and selective DNA-PK inhibitor with IC50 of 14 nM and also inhibits mTOR and PI3K with IC50 of 1.7 μM and 5 μM in cell-free assays, respectively. It reduces the frequency of NHEJ while increasing the rate of HDR following Cas9-mediated DNA cleavage.
Storage Conditions
2 years -80 in solvent
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