Rabusertib (LY2603618)
Product Specifications
CAS Number
911222-45-2
Synonyms
IC-83
Target
Chk
Applications
Cell Cycle
Smiles
CC1=CC (=C (C=C1Br) NC (=O) NC2=NC=C (N=C2) C) OCC3CNCCO3
Molecular Formula
C18H22BrN5O3
Additionnal Information
Rabusertib (LY2603618, IC-83) is a highly selective Chk1 inhibitor with potential anti-tumor activity in a cell-free assay. IC50=7 nM, showing approximately 100-fold more potent against Chk1 than against any of the other protein kinases evaluated. Rabusertib (LY2603618) induces cell cycle arrest, DNA damage response and autophagy in cancer cells. Rabusertib (LY2603618) induces bak-dependent apoptosis in AML cell lines.
Storage Conditions
2 years -80 in solvent
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